Cleveland, OH — Researchers at Case Western Reserve University have made a hopeful breakthrough in developing a new treatment for Alzheimer’s, TBI, and brain disorders: a drug that preserves memory without reducing amyloid plaque levels. The study also shows promising results for treating traumatic brain injury (TBI).
A New Approach: Strengthening the Blood-Brain Barrier
Most current Alzheimer’s treatments focus on removing amyloid protein plaques, but clinical results have been limited and often come with dangerous side effects. This new study takes a different route—protecting the blood-brain barrier (BBB), a critical cellular layer that shields the brain from toxins and harmful substances.
Dr. Andrew Pieper, a psychiatrist and researcher at University Hospitals Cleveland Medical Center, explained that the study focused not on neurons but the brain’s outer perimeter, where the BBB resides.
What Is the Drug SW033291?
The tested drug, SW033291, works by blocking an enzyme called 15-PGDH, which scientists found to be highly active in Alzheimer’s models and associated with significant brain damage.
In experimental trials, mice treated with SW033291:
- Maintained an intact BBB
- Showed no memory loss
- Retained normal neuron function
- Performed well in cognitive tests
Promising Results in Traumatic Brain Injury (TBI)
Researchers also tested the drug on mice with brain trauma resembling a concussion. Treatment began one day after the injury, and the results were encouraging:
- Mice did not develop typical concussion symptoms, memory issues, or motor deficits
- Neurological damage was significantly reduced
These findings suggest the drug could benefit not only those with degenerative diseases like Alzheimer’s, but also patients with TBI at risk of developing long-term cognitive decline.
What Makes This Drug Different?
Unlike current Alzheimer’s medications that target brain amyloid, SW033291 does not alter amyloid levels, yet it still preserves memory. This marks a radical shift in treatment strategy:
- Fewer potential side effects (such as inflammation or brain bleeding)
- Brain function is preserved without directly modifying internal brain chemistry
- Early intervention may prevent long-term deterioration
“This new approach focuses on limiting damage from the outset to allow the rest of the brain to function normally,” explained Dr. Sanford Markowitz, co-author of the study.
What Does This Mean for Alzheimer’s and TBI Patients?
While human trials have yet to begin, this discovery brings new hope to millions facing neurodegenerative diseases or long-term consequences from brain injury.
At the Brain Injury Help Center (BIHC), we closely monitor developments like this to connect our clients with innovative treatments and provide:
✔️ Personalized medical and legal guidance for those with TBI from accidents
✔️ Access to updated neurological assessments and clinical research centers
✔️ Expert legal representation for brain injuries caused by negligence, accidents, or workplace exposure
Get the medical care you need and the compensation you deserve
📞 Contact us today for a free consultation if you or a loved one has been diagnosed with traumatic brain injury or progressive memory loss following an accident. We’re here to help.
